{"id":800,"date":"2026-02-02T16:22:25","date_gmt":"2026-02-02T15:22:25","guid":{"rendered":"https:\/\/grossicardiologo.it\/?p=800"},"modified":"2026-03-20T15:49:22","modified_gmt":"2026-03-20T14:49:22","slug":"specialista-sindrome-brugada","status":"publish","type":"post","link":"https:\/\/grossicardiologo.it\/en\/specialista-sindrome-brugada\/","title":{"rendered":"Specialista Sindrome di Brugada"},"content":{"rendered":"
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Brugada Syndrome<\/h1>\n\n\n\n
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A \"silent\" disease<\/h2>\n\n\n\n

Knowing it to treat it<\/h3>\n\n\n\n

An \"electrical\" pathology, genetically determined, that affects structurally healthy hearts. It remains silent without showing signs until an arrhythmia suddenly occurs.<\/p>\n\n\n\n

Correct information is the first step toward safety.<\/p>\n\n\n\n

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Details<\/a><\/div>\n\n\n\n
How it is diagnosed<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
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"Responsible for 4-12% of all cases of sudden cardiac death".<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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The roots of Italian excellence<\/h2>\n\n\n\n

Described by the Brugada brothers in 1992, the syndrome boasts pioneering studies in Italy. Already in the 1980s, cardiologists Nava, Martini, and Thiene <\/strong><\/strong> outlined its characteristics in the Giornale Italiano di Cardiologia.<\/p>\n\n\n\n

Known in Asia as Lai Tai<\/em> or Bangungut<\/em>it represents a crucial clinical challenge: it affects the heart's ion channels even in the presence of a structurally healthy muscle.<\/p>\n\n\n\n

The syndrome shows a marked prevalence in males, with a ratio of 8 to 1<\/strong> compared to women. Symptoms most frequently\nmanifest in the young-adult age group, typically between 30 and 40 years<\/strong>.<\/p>\n<\/div>\n\n\n\n

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1-30<\/strong><\/p>\n\n\n\n

cases per 10,000<\/p>\n<\/div>\n\n\n\n

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>20%<\/strong><\/p>\n\n\n\n

of deaths in healthy hearts<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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Causes and genetic transmission<\/h2>\n\n\n\n

An \"electrical disease\" caused by minimal alterations in a small area of the heart.<\/p>\n\n\n\n

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Dominant Inheritance<\/h3>\n\n\n\n

50% probability of transmission.<\/p>\n\n\n\n

Only one parent with the anomaly is enough to transmit the predisposition to the children.<\/p>\n<\/div>\n\n\n\n

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Gene Anomaly<\/h3>\n\n\n\n

In 40% of cases, the responsible gene is identified. The most frequent is SCN5A, which regulates sodium channels.
In the remaining 60%, research is still trying to identify the responsible genes.<\/p>\n<\/div>\n\n\n\n

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Prevention, not panic.<\/h3>\n\n\n\n

Having the gene does not mean manifesting the disease. Many will never have
arrhythmic events. After diagnosis, a risk assessment is necessary.<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n

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When the heart sends signals<\/h2>\n\n\n\n

About 70%<\/strong> of patients are asymptomatic. Symptoms usually appear between ages 30 and 40, typically at rest or during sleep.<\/p>\n\n\n\n